Urine (2% to 4% as unchanged drug) feces Onset of Action Hepatic (extensive first-pass effect) via CYP-450 and conjugation forms metabolites N-monodesmethyldiltiazem, desacetyldiltiazem, desacetyl-Nmonodesmethyldiltiazem, desacetyl-O-desmethyldiltiazem, and desacetyl-N, O-desmethyldiltiazem following single IV injection, plasma concentrations of N-monodesmethyldiltiazem and desacetyldiltiazem are typically undetectable however, these metabolites accumulate to detectable concentrations following 24-hour constant rate infusion. Immediate release tablet: ~98% Extended release capsule: ~93% to >95% Distribution Pharmacokinetics/Pharmacodynamics Absorption Inhibits calcium ion from entering the “slow channels” or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarization produces relaxation of coronary vascular smooth muscle and coronary vasodilation increases myocardial oxygen delivery in patients with vasospastic angina. Tablet Extended Release 24 Hour, Oral, as hydrochloride:Ĭardizem LA: 120 mg, 180 mg, 240 mg, 300 mg, 360 mg, 420 mg
Solution Reconstituted, Intravenous, as hydrochloride:Ĭardizem: 30 mg Ĭardizem: 60 mg Ĭardizem: 120 mg Solution, Intravenous, as hydrochloride :
= Discontinued productĬapsule Extended Release 12 Hour, Oral, as hydrochloride:Ĭapsule Extended Release 24 Hour, Oral, as hydrochloride:Ĭardizem CD: 120 mg, 180 mg, 240 mg, 300 mg, 360 mg Ĭartia XT: 300 mg ĭilt-XR: 120 mg, 180 mg, 240 mg ĭilTIAZem CD: 180 mg ĭilTIAZem CD: 240 mg Excipient information presented when available (limited, particularly for generics) consult specific product labeling.
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